Fort Myers and the adjacent and quite famous Sanibel Island region lies along southwest Florida's pristine Gulf Coast. Although it's not a major market with gay and lesbian visitors, this city of 65,000 (with a metro area of some 625,000) does have a handful of fun and lively gay nightspots, as well as numerous appealing places to eat, especially if you include the larger neighboring (and fast-growing) city of Cape Coral and the hugely popular beach resort of Sanibel Island. The region also hosts the Southwest Florida Gay Pride celebration each year in October, taking place in the city of Cape Coral.
Extremely popular is the neighborhood gay bar Rascals (3758 Cleveland Ave.). Rascals has a number of friendly promotions, including free billiards on Mondays and a very well-attended country-western night on Thursdays. The attractive space is good for dancing, and there are some great drag shows and other parties, as well as "Bears Night Out" gatherings.
Naples, which is just 45 miles south, has great gay nightlife options. To the north, it's less than a two-hour drive to reach gay-popular St. Petersburg and Tampa, and just a 90-minute drive to get to Sarasota.