You need a hotel with some space, but you also want something that is different. Delano Las Vegas has to be your command center for the ultimate girls getaway. It's close to everything while being just far away enough to make sure you don't run into anyone you know. It's connected to Mandalay Bay so you get the benefits of a big resort while still feeling like a boutique property. The Mandalay Bay Pool is great but if you need a smaller pool to bask in the sunshine the Delano Beach Club is just right.
You'll have to eat, so you might as well eat very well. Le Cirque at Bellagio is amazing, or try Rivea at Delano or Costa Di Mare at Wynn. You'll need drinks before, so consider the Skyfall Lounge at Delano or Parasol Down at Wynn. If the girls want to let loose while eating try STK at Cosmopolitan, as it feels like a nightclub opened up around a steakhouse.
You will need a spa treatment, so there is no reason to go anywhere but the bathhouse at Delano. There is no worse way to ruin a good day at the spa then getting in a cab and driving back to your hotel. At the bathhouse, you linger for the better part of the day and then you stroll back to your room and get ready for the evening.
Late night only means that you will hop into a cab and change venues until the sun comes up. Hakkasan at the MGM Grand takes care of everything for the entire night. You can start with dinner and move on to drinks and then glide into dancing. This multi-level club has everything you require to get the crew into a full-blown Las Vegas frenzy.
As the sun comes up, you should get a good spot at the pool. Take your pick of the best pools in Las Vegas and recharge for another girls' night out.
Once the girls get to TAO at the Venetian the vultures will start circling, but the best part of Tao is that it is laid out in such a way that you can still get free drinks while not being hounded by too many guys. Spend the extra money and go VIP for the girls' weekend out and you will not be disappointed.