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Our Top Picks
Best Overall: EcoRaider Bed Bug Killer at Walmart
"This 16-ounce spray bottle is easy to use and perfect for spraying into cracks and crevices, where those sneaky bugs like to hide."
Best Odorless: Harris Toughest Bed Bug Killer at Amazon
"This spray kills bed bugs on contact, while also eliminating their eggs and continuing to kill bed bugs for up to 16 weeks."
Best for Travel: Travel Hygea Natural Exterminator Spray at Amazon
"Spritz your luggage when you’re leaving, so bugs don’t try to hitch a ride with you."
Best Multi-Purpose: All Natural Eucoclean Bed Bug, Flea & Dust Mite Killer at Walmart
"Formulated with botanical essential eucalyptus oil, it safely eliminates bed bugs."
Runner-Up, Best Overall: Eco Defense Bed Bug Killer at Walmart
"This stuff really works, killing adult bed bugs, nymphs and eggs quickly."
"This non-toxic, plant-based spray has been extensively lab-tested and proven to kill dust mites, bed bugs and their eggs on contact."
Best Natural: Bye Bye Bed Bugs at Amazon
"It’s made of all-natural, eco-friendly ingredients and specifically formulated to be used on bedding and mattresses."
Our Top Picks
Best Overall: EcoRaider Bed Bug Killer
EcoRaider Bed Bug Killer spray gets our top ranking for its overall effectiveness and affordability. A certified USDA BioBased insecticide, it’s also non-toxic, safe and eco-friendly, so you can use it around pets and kids and spray it directly on your mattresses, carpets and furniture. This formula is made of all-natural, botanical ingredients, and has a pleasant cedar/eucalyptus scent that dissipates quickly after application. EcoRaider Bed Bug Killer is effective in all stages of bed bugs, including adults, nymphs and eggs, even killing bed bugs that have built up a resistance to traditional pesticides. Its long-term effectiveness has also been studied, with results showing it continues to protect against bed bug for two weeks after application.
This 16-ounce spray bottle is easy to use and perfect for spraying into cracks and crevices, where those sneaky bugs like to hide. EcoRaider also comes in a gallon jug size, if you need to refill your bottle or anticipate a big job. It’s also available in a convenient travel-size bottle that you can easily pack in your suitcase.
Best Odorless: Harris Toughest Bed Bug Killer
Some bed bug sprays have a powerful stench that takes a long time to dissipate. And, in some cases, you may not be able to open windows to air out the room after you’ve sprayed. Harris Toughest Bed Bug Killer is an odorless formula that’s a great option if ventilation is an issue, you’re particularly sensitive to smells or you just don’t want that lingering bad odor. This spray kills bed bugs on contact, while also eliminating their eggs and continuing to kill bed bugs for up to 16 weeks after application. In addition to being scent-free, it also won’t stain or damage fabrics. It’s registered with the EPA and is safe to use around people and pets. This gallon bottle is the perfect size when you need to spray a few rooms or plan to do multiple treatments.
Best for Travel: Travel Hygea Natural Exterminator Spray
Another non-toxic option, this bed bug spray comes in a travel size, so it’s perfect to pack along in your suitcase – and then use to spray the mattress, sheets and any areas that look suspect once you get to your destination. You can also spritz your luggage when you’re leaving, so bugs don’t try to hitch a ride with you. The enzyme formula is odorless, won’t leave a residue and will exterminate bed bugs on contact, without harming people or pets. The three-ounce bottle size is TSA-approved, so you can carry it on a plane in your checked bag without a problem.
Best Multi-Purpose: All Natural Eucoclean Bed Bug, Flea & Dust Mite Killer
This spray from Eucoclean is a fantastic all-in-one product to help you get rid of pests, as well as clean and deodorize your home. Formulated with botanical essential eucalyptus oil, it safely eliminates bed bugs, as well as dust mites, fleas, lice, ants, ticks, spiders and moths. You can also use it to clean and deodorize surfaces, from kitchen countertops to floors to toilets. Users love the fresh scent and they proactively spray it to prevent future bug infestations. One downside is that it’s only available in a 750ml bottle so, if you’re spraying in multiple areas, you’ll most likely go through it rather quickly.
Runner-Up, Best Overall: Eco Defense Bed Bug Killer
If you’re looking for a spray that’s safe to use around pets and kids, the Eco Defense Bed Bug Killer is made of completely natural, organic, USA-sourced and non-toxic ingredients. You don’t have to stay out of your house for days after treatment or worry about being exposed to fumes and pesticides. And this stuff really works, killing adult bed bugs, nymphs and eggs quickly. It’s also effective on other bugs, including dust mites and lice. You can apply it directly to sheets, mattresses and mattress covers, carpet, upholstered furniture and even clothes. Eco Defense won’t stain the fabric or irritate your skin.
Best Budget: Proof 100% Effective Bed Bug and Dust Mite Killer Spray
If you’ve got problems with bed bugs and dust mites, you can eliminate them both at the same time with Proof 100% Effective Bed Bug and Dust Mite Killer Spray. This non-toxic, plant-based spray has been extensively lab-tested and proven to kill dust mites, bed bugs and their eggs on contact. It also continues to eliminate them for up to three weeks after treatment, when used as directed. It’s a bit cheaper compared to other bed bug sprays, but still highly effective.
Best Natural: Bye Bye Bed Bugs
Bye Bye Bed Bugs spray will give you peace of mind that you’re eliminating those nasty bed bugs, but also keeping your pets and kids safe. It’s made of all-natural, eco-friendly ingredients and specifically formulated to be used on bedding and mattresses. It also won’t leave behind any stains – only dead bugs! This 32-ounce bottle is super easy to hold and has a few different spray patterns, so you can get the formula into every nook and cranny where the bugs may be hiding. With a scent that’s more pleasant and tolerable than some other bed bug sprays, it can also be used as a preventive spray. For some extra protection, you can spritz your luggage with it before packing for a trip.
What to Look for in Bed Bug Spray
Eco-friendliness While chemicals can definitely pack a punch, you don’t have to load up on toxic chemicals to get rid of bed bugs. You can purchase safe, eco-friendly sprays that will eliminate the critters while still being safe around kids and pets—and we highly recommend doing so.
Odor Bed bug sprays don’t exactly smell like perfume, and some are downright stinky, with a stench that can linger in the hotel room, your bed, or your suitcase for hours. Considering some hotel rooms don’t have windows that open, look to odorless sprays that are high on bed bug extermination power and low on smell.
Size Unfortunately, the TSA isn’t going to make a special exemption for bed bug spray when it comes to your luggage allowance, so as much as you might want to look for a gallon-size container of the stuff, we recommend looking for a spray with a volume that’s already TSA-acceptable, or one that’s easy to distill into your own travel-size container (just make sure it’s leak-proof!).